Cathepsin-D and nm23 provide the predictive value of response to anthracycline-based neoadjuvant chemotherapy in breast cancer
CHEN Yi-zuo
CHEN Can-ming
FEI Fei
ZHANG Jia-xin
LU Jin-song
DI Gen-hong
LIU Guang-yu
YANG Wen-tao
LU Hong-fen
SHEN Kun-wei
SHEN Zhen-zhou
SHAO Zhi-min
WU Jiong
Abstract：Objective To investigate the predictive value of biological markers for responsiveness to anthracyline-based regimen in neoadjuvant systemic therapy. Methods Post-operative paraffin-embedded tumor samples from 173 breast cancer patients were examined for expression of ER、PR、Her-2/neu、and other 15 markers by immunohistochemistry, to analyze the predictive value of these biological markers for response to neoadjuvant chemotherapy. Results For the primary tumor, the clinical objective response was 66.47%, 29.48%SD,and 4.05% PD. Pathological complete response was found in 3 cases(1.73%).Negative nm23, and loss of Cathepsin-D were significantly predictive for an effective response to anthracycline-based neoadjuvant chemotherapy. In multivariate logistic regression analysis, only the Cathepsin-D status was found for independent predictive value. Conclusion Loss of Cathepsin-D independently predicts the response to anthracycline-based regimen.
Keywords：Breast cancerNeoadjuvant chemotherapyPredictive factorsImmunohistochemistry
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 59-62 )