Directive value of lactate clearance and central venous oxygen saturation in the patients with severe sepsis or septic shock
ZHENG Zhen
LI Zhi-liang
AN Xin
ZHANG Zhi-dan
MA Xiao-chun
Abstract：Objective To evaluate the efficacy of the lactate clearance and central venous oxygen saturation(ScvO_2)directed therapy in severe sepsis and septic shock.Methods According to the goal of therapy,74 patients with severe sepsis or septic shock admitted between January 2006 and December 2006 at the Department of ICU,the First Hospital of China Medical University were assigned into three groups:A group(fluid resuscitation for 72 hours);B group(fluid resuscitation and ScvO_2≥70%for 72 hours);C group(fluid resuseitation and laetate clearance≥10%for 72 hours).Results The rates of MODS in B group and C group were lower than that in C group(33.3%vs 54.5%;28.6%vs 54.5%,P<0.05).Mortality rate at 7 day in C group was lowerthan that in A group(P<0.05).Monality rates in B group and C group were lower than that in A group.Time of stay in ICU in B group and C group were shorter than that in A group(P<0.05).Conclusion Therapy directed by lactate clearance and ScvO_2 is associated with decreased mortality rate and rate of MODS in patients with severe sepsis or septic shock.
Keywords：sepsisseptic shockfluid resuscitation
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1009-1011 )