Clinical intervention study of low molecular heparin (LMH) and coagulopathy in critical post-surgical patients with infection
Abstract：Objective To observe the index of blood coagulation,intervention treatment and safety of low molecular heparin(LMH)in critical post-surgical patients with infection.Methods The clinical data of 200 critical post-surgical patients with infection in the Department of SICU of Second Affiliated Hospital of Kunnfing Medical College between October 2006 and August 2009 as study group and 100 non-infection patints as comparative group in synchronization.The study group was randomly divided into infection group that 100 patients were treated regularlv of ICU,and LMH treatment group that 100 patients were taken 40mg LMH by a subcutaneous injection twice Per day on regular treatment in post-surgical 8 hours.All patients of study group and comparative group were observed regularly by ICU.PT,APTT,TT,FIB and side effect of Hepafn such as hemorrhage in 7 clays were observed.The patients accorded with the transfer criteria of ICU were gotten out from ICU dunng observation time.Results (1)PT and APTT in all patients with infection compared with non-infection were time-lapse in post-surgical 1 to 7 days(P<0.01),and TT was time-Iapse a little bit but hmated in normal range in post-surgical 6 to 7 days.FIB in all groups were similar in the first day(p> 0.05).However,FIB in all of infection patients increased compared with that of comparative group in 2 to 7 davs(P< 0.01).(2)PT in LMH treatment group was shorter than infection group's in post-surgical 4 to 7 davs.APTT was time--lapse compared with that of infection group in post-surgical 5 to 7 days.TF did not change.FI B in LMH treatment group decreased compared with that of comparative infection group(P<0.01).(3)The proportion of getting out from ICU in LMH treatment group was higher than that of regular treatment group as observation was over(P<0.01).The time in ICU was not different(P>0.05).(4)lniection sites of three patients in LMH treatment group presented ecchymosis.Conclusion Critical post-surgical patients with infection usually accompany by phenomenon of coagulation activation and fibrinolytic inhibition.Eady treannent bv LMH in post-surgical patients with infection might improve coagulation activation and fibrinolytic inhibition,increase effect of combined therapy and have good safety.
Keywords：post-surgical patientseoagulopathylow molecular heparin
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1003-1005,1021 )