Role of glucocorticoids in the treatment of septic shock
JI Xian-fei
LI Chun-sheng
Abstract：The use of glucocorticoids in septic shock patients has been controversial for decades.High-dose glucocortieoids were standard therapy in the 1 970s and 1 980s.During the late 1980s.the consensus was that glueoeorticoids should not be used in sepsis and septic shock after two studies with broad scale had not shown an improved survival,even had been harmful for patients treated with steroids.Studies in the late 1 990s and early 2000s demonstrated the lower doses of glucocorticoids for longer periods would reverse shock and even improve survival.However,the recent CORTICUS study did demonstrate the lower doses of glucocorticoids increased incidence of superinfection including new sepsis or septic shock,but did not decrease 28-day mortality rate.It is noteworthy that the efficacy and safety of glucocorticoids in sepsis have been investigated in randomized controlled trials for half a century,and still,the treatment remains controversial.
Keywords：glucocorticoidsseptic shockhydrocortisone
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 989-992 )