Study on the correlation between ketosis episodes and risk of atherosclerosis in patients with newly-onset ketosis-prone type 2 diabetes
ZHU Hai-wei
LIANG Lin-lang
YU Hao
WANG Yu
LI Yu-jie
Abstract：Objective To investigate the correlation between ketosis episodes and lipid-related parameters in patients with newly-onset ketosis-prone type 2 diabetes(KPT2DM),and further assess the impact of ketosis episodes on AS risk.Methods A cross-sectional study was performed in 157 subjects with newly-onset diabetes,who visited Northern Theater Command General Hospital for treatment from Jan.2022 to Oct.2023,including 87 subjects in KPT2DM group and 70 in T2DM group.Anthropometric and biochemical parameters were measured in all subjects.Calculate the atherogenic index of plasma(AIP)by traditional lipid parameters.Results The AIP level(P=0.048)and the percentage of AIP ≥ 0.24(P=0.047)in subjects with KPT2DM were higher than those in subjects with T2DM,and the differences were statistically significant.In the KPT2DM group,plasma ketones were positively correlated with AIP(P=0.016).Univariate logistic regression analysis showed that plasma ketone(OR=1.491,P=0.048)was an important related factor for the AS in subjects with KPT2DM.Multiple linear regression analysis showed that plasma ketone had significantly positive correlation with AIP(β=0.201,P-0.045).Conclusion Ketosis episodes in patients with KPT2DM are significantly and positively associated with elevated AIP levels.Frequent ketosis episodes may accelerate the progression of AS.
Keywords：ketosis episodesketosis-prone type 2 diabeteslipid metabolismatherosclerosisatherogenic index of plasma
Publication Date：2025-11-01
Online Publishing Date：2025-12-10(First online date of this platform, not the publication date of the document)
Pages：5( 957-961 )