Study on the correlation of serum monoamine oxidase and inflammatory markers with the severity of coronary artery lesions
ZHAO Xiao-tong
CAO Qian
Abstract：Objective To investigate the correlation of monoamine oxidase(MAO),monocyte-to-lymphocyte ratio(MLR),neutrophil-to-lymphocyte ratio(NLR)and neutrophil-to-high-density lipoprotein ratio(NHR)with coronary heart disease(CHD),and to explore whether they are associated with the severity of coronary artery lesions.Methods Totally 617 patients who underwent coronary angiography in the Department of Cardiovascular Medicine of Shengjing Hospital Affiliated to China Medical University from July 2022 to December 2023 were included,and they were divided into two groups:451 cases in the CHD group and 166 cases in the non-CHD group.Differences in MAO,MLR,NLR,and NHR were compared between the two groups.The CHD group was further divided according to the Gensini scoring standard.The correlation between Gensini score and MAO,MLR,NLR,NHR was analyzed to assess their relationship with the severity of coronary artery lesions.Results Patients in the CHD group had higher levels of MAO,MLR,NLR,and NHR than those in the non-CHD group,with statistically significant differences(P＜0.05).Binary logistic regression analysis was conducted on the statistically significant indicators of the two groups,and the results showed that the two indicators had statistical differences:MLR(OR=1.05,95％CI 1.03-1.07,P＜0.001),and MAO(OR=1.70,95％CI 1.48-1.94,P＜0.001).Among the groups divided by different Gensini scores,the group with the highest score had higher NHR(4.97)and MAO(6.10 U/L)than the group with the lowest score[NHR(4.07),MAO(5.09 U/L)],and the difference was statistically significant(P＜0.05).Conclusion MLR and MAO have certain predictive value for the occurrence of CHD.Among groups with different Gensini scores,NHR and MAO are associated with the severity of coronary artery lesions.
Keywords：coronary heart diseaseinflammatory reactionmonoamine oxidaseratio of monocytes to lymphocytesratio of neutrophils to lymphocytesratio of neutrophils to high-density lipoproteinGensini score
Publication Date：2025-11-01
Online Publishing Date：2025-12-10(First online date of this platform, not the publication date of the document)
Pages：5( 952-956 )