Research progress on cognitive continuum spectrum,its transformation and pathological markers of Alzheimer's disease
MAO Ming
TIAN Min-le
LI Xue-wei
CHEN ZI-wei
HAN Xiao-juan
Abstract：Alzheimer's disease(AD)is a progressive neurodegenerative disorder characterized by β-amyloid deposition,hyperphosphorylated tau pathology,and neuronal loss,which could begin 10-20 years before onset of clinical symptoms.Advances in biomarker research and the concept of the cognitive continuum have shifted the diagnosis of AD from a clinically based framework to a biology-centered approach.Blood-based and neuroimaging biomarkers now enable early screening and diagnosis,and predict disease progression and prognosis.Furthermore,the trajectory of AD cognitive continuum is influenced by genetic factors,comorbidities,lifestyle,and cognitive reserve.Multimodal interventions,anti-amyloid immunotherapies,digital tools,and neuromodulation devices offer promising strategies for early interventions,contributing to delayed disease progression and improved outcomes.
Keywords：Alzheimer's diseasecognitive continuumdisease transitionmultimodal intervention
Publication Date：2025-10-01
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：5( 823-826,837 )