Predictive value of serum intestinal fatty acid-binding protein in the risk of rebleeding in patients with hepatitis B cirrhosis and esophagogastric variceal
HAN Cai-jun
WU Zheng-xie
HUANG Yuan
JIN Xing
ZHANG Xiang-lan
Abstract：Objective To explore the clinical predictive value of serum intestinal fatty acid-binding protein(Ⅰ-FABP)for the risk of rebleeding within 1 year in patients with hepatitis B cirrhosis and esophagogastric variceal bleeding(EVB).Methods We retrospectively analyzed the clinical data of patients with hepatitis B cirrhosis and EVB admitted to the Affiliated Hospital of Yanbian University between September 2020 and March 2024.Patients were divided into rebleeding and non-rebleeding groups based on whether bleeding occurred during the 1-year follow-up period.An enzyme-linked immunosorbent assay was used to measure the baseline Ⅰ-FABP level upon admission.Kaplan-Meier analysis was used to compare the risk of rebleeding between groups stratified by Ⅰ-FABP quartile,while a restricted cubic spline(RCS)was used to explore potential linear relationships between Ⅰ-FABP and rebleeding risk.Multivariate Cox proportional hazards regression models were used to assess the association between Ⅰ-FABP and rebleeding risk.Receiver operating characteristic(ROC)curves were constructed to assess the accuracy of the relevant factors in predicting rebleeding.Results A total of 137 patients were included in the study.After 1 year of follow-up,the recurrent rebleeding rate was 42.3％(58/137).The median time torebleeding was 4.2(1.8,7.5)months.Kaplan-Meier analysis indicated that patients with higher Ⅰ-FABP levels had a higher risk of rebleeding(log-rank x2=17.84,P＜0.001).Restricted cubic spline revealed that a linear relationship between Ⅰ-FABP and rebleeding(P-nonlinear=0.288,P=0.001).Multivar-iable Cox regression analysis identified Ⅰ-FABP as an independent factor contributing to rebleeding(hazard ratio=1.723,95％CI 1.340-2.216,P＜0.001).ROC curve showed that Ⅰ-FABP had a certain predictive efficacy for rebleeding.The area under the curve was 0.695(95％CI 0.611-0.771).Conclusion Ⅰ-FABP remained strongly linked to the risk of rebleeding and demonstrated good predictive value.
Keywords：cirrhosisesophagogastric varicealbleedingintestinal fatty acid-binding protein
Publication Date：2025-07-01
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：7( 606-612 )