Analysis of hematology ICU treatment of patients with hematological malignancies complicated with critical COVID-19
LI Qian
XIE Yan
LIANG Pei-qi
LIU Zi-yi
WANG Dong
GAO Meng
LI Wei-yang
WANG Ying
WU De-pei
FU Jian-hong
Abstract：Objective To retrospectively analyze the treatment of patients with hematological malignancies(HM)complicated with critical coronavirus disease 2019(COVID-19)in the hematology intensive care unit(ICU).Methods The study included patients with hematological malignancy and critical COVID-19 admitted to the hematology ICU of the First Affiliated Hospital of Soochow University from December 15,2022,to March 10,2023.Demographic data,clinical manifestations,laboratory and imaging examination indicators,clinical scores and treatment methods were collected by case questionnaire.According to the prognosis,the patients were divided into death group and survival group,and the differences between the two groups were compared.Results A total of 27 patients were enrolled,including 19 patients(70.37％)aged 18-64 years and 8 patients(29.63％)aged ≥65 years.There were 13 males(48.15％)and 14 females(51.85％).Among different hematological malignancies,14 cases(51.85％)were leukemia,8 cases(29.63％)were lymphoma,3 cases(11.11％)were plasma cell diseases,and 2 cases(7.41％)were MDS.Eleven patients(40.74％)were in post-hematopoietic stem cell transplantation status,7 patients(25.93％)received endotracheal intubation mechanical ventilation support,20 patients(74.07％)received non-invasive mechanical ventilation support,4 patients received CRRT support,and 10 patients received vasopressor drug osupport.In this study,the mortality of patients with hematological malignancies and critical COVID-19 was 44.4％(12/27).The comparison between the two groups showed that the white blood cell(WBC)and neutrophil(ANC)count levels in the death group were lower,the time from the onset of COVID-19 to the hematology ICU was shorter,the sequential organ failure assessment(SOFA)score was higher,and the patients received more mechanical ventilation and vasopressor drug support.Conclusion Patients with hematological malignancies are vulnerable population in the epidemic of 2019-ncov infection.Lower WBC and ANC,and vasopressor therapy are associated with higher mortality.Hematology ICU can provide comprehensive life support for these patients.
Keywords：hematologic malignanciescoronavirus disease 2019(COVID-19)intensive care unit
Publication Date：2025-07-01
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：6( 600-605 )