Interpret of Preferred Reporting Items for Microbiotherapy Guidelines(PRIM 2024)
ZHANG Zu-lun
WU Xia
CUI Bo-ta
ZHANG Fa-ming
Abstract：In recent years,the research on microbiotherapy(such as fecal microbiota transplantation,probiotics,phage therapy,oncolytic bacteria,oncolytic viruses,etc.)for diseases has been increasing.However,due to the lack of a unified reporting guideline,many studies have failed to cover all the necessary reporting items required by medical practitioners,researchers,and readers,thereby hindering result reproducibility,safety evaluation,and technological implementation.In 2024,an international multidisciplinary panel of clinical experts from eight countries established the Preferred Reporting Items for Microbiotherapy(PRIM 2024)international guidelines through a Delphi consensus procedure.The PRIM 2024 guidelines included 10 statements and 18 points on diagnosis,delivery route,source,classification,preparation,dosage,state,concomitant treatment,efficacy,and safety.This article introduces and interprets the core components of the guidelines,aiming to provide methodological guidance for clinical research report and establish a foundational framework and reference for standardizing diagnosis and treatment practice in microbiota medicine.
Keywords：microbemicrobiotherapymicrobiota medicineguidelinespecificationstandard
Publication Date：2025-07-01
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：5( 588-592 )