Management of common complications and comorbidities in paroxysmal nocturnal hemoglobinuria
JIA Jin-song
Abstract：This article reviews the management strategies for common complications and comorbidities of paroxysmal nocturnal hemoglobinuria(PNH),with a focus on addressing thrombosis,chronic renal insufficiency,pulmonary hypertension,bone marrow failure,and infections.Key strategies include:using complement inhibitors as the cornerstone to reduce thrombosis and hemolysis risks,combining anticoagulation therapy to prevent thrombotic events,protecting renal function through supportive care,and employing targeted medications to improve pulmonary hypertension.Immunosuppressive therapy or hematopoietic stem cell transplantation is utilized to correct bone marrow failure,while enhanced vaccination and antibiotic prophylaxis are emphasized to prevent infections.The article also covers special issues such as iron metabolism disorders and pregnancy management,highlighting the importance of multidisciplinary collaboration.
Keywords：paroxysmal nocturnal hemoglobinuriacomplicationscomorbidities
Publication Date：2025-07-01
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：7( 564-569,587 )