Efficacy evaluation of complement inhibitors and clinical follow-up of paroxysmal nocturnal hemoglobinuria
HAN Bing
Abstract：Recently,the development and clinical application of complement inhibitors have significantly improved the survival and quality of life of patients with paroxysmal nocturnal hemoglobinuria(PNH).The treatment goal of PNH has been upgraded from hemolysis control to transfusion independence and hemoglobin normalization.Even with the initial control of hemolysis with compliment inhibitors,there is still questions like breakthrough hemolysis,extra vascular hemolysis,thrombotic events or disease evolution due to the diversities of PNH.Because PNH clones generally do not disappear after compliment inhibitors,patients require long-term follow-up and life-long time management which is similar to the management of chronic disease.Patient reports,clinical assessments,laboratory data,efficacy assessments need to be integrated to improve the quality of life of patients.
Keywords：paroxysmal nocturnal hemoglobinuriaefficacy assessmentfollow-up
Publication Date：2025-07-01
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：5( 554-558 )