Significance and evaluation of novel molecular diagnosis methods for early lung cancer
WANG Zi-qi
ZHANG Xiao-ju
Abstract：The early diagnosis of lung cancer is crucial to increasing the survival rates of patients,and molecular diagnosis methods represents a new direction.Research on molecular biomarkers for early-stage lung cancer diagnosis is showing a multi-dimensional development trend.The model constructed by traditional protein biomarkers combined with imaging features can enhance risk prediction efficacy,but its sensitivity for sub-centimeter nodules remains insufficient.Novel biomarkers such as ProGRP and circulation tumor DNA(ctDNA)methylation have significantly improved detection performance through technological innovations,yet many biomarkers are still limited by low sensitivity.Current challenges focus on the limitations of biomarker sensitivity,the lack of survival benefit evidence,and unclear clinical translation pathways.Future advancements call for multi-dimensional integration and liquid biopsy innovations to drive breakthroughs in early diagnosis,ultimately achieving a shift of diagnosis and treatment paradigm from"treating advanced cancer"to"preventing early cancer".
Keywords：early-stage lung cancermolecular diagnosisliquid biopsy
Publication Date：2025-06-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 449-453 )