Some issues deserving attention in the diagnosis and treatment of diabetic kidney disease
CHEN Xiao-jun
SUN Lin
Abstract：There are some issues that are often neglected by clinicians in clinical diagnosis and treatment of diabetic kidney disease(DKD).Firstly,the definitions of diabetic nephropathy(DN),DKD,and diabetes mellitus in chronic kidney disease(DM in CKD)should be clarified.DN is characterized by kidney-specific histopathological changes due to DM,which is confirmed by biopsy.DKD,used for non-biopsy clinical diagnosis,is widely applied at present,while DMinCKD includes all CKD types in DM patients.Secondly,renal function in DKD patients usually declines slowly,but some patients experience continuous eGFR decline[＞7 ml/(min·1.73 m2)per year or＞4％per year],which presents as rapidly progressive type,and hematuria often occurs in patients with interstitial inflammation.DKD crescents,different from inflammatory crescents,may be formed during the self-repair process of injured glomerular cells differentiating into podocytes,and the prognosis is poor.Enhanced recognition of these issues is crucial for improving DKD's prevention and management.
Keywords：diabetic kidney diseaserapidly progressive diabetic nephropathyhematuriacrescents
Publication Date：2025-03-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 199-203,209 )