Clinical application of aerosol inhalation therapy
WEN Ruo-xuan
HU Xing-shuo
XIE Li-xin
Abstract：Ultrasonic nebulizers,jet nebulizers,pressurized metered-dose inhalers,and vibrating mesh nebulizers are several commonly used nebulization devices in clinical practice.Ultrasonic nebulizers produce good nebulization effects but primarily act on the oropharynx,limiting their clinical application;jet nebulizers are widely used clinically but have slightly inferior nebulization effects compared to other devices;pressurized metered-dose inhalers offer good nebulization effects but are complex to operate;vibrating mesh nebulizers provide the best nebulization effects but are more expensive.As aerosol therapy continues to be widely applied clinically,ensuring the effectiveness of aerosol delivery for patients receiving different types of respiratory support(such as high-flow nasal cannula,invasive and non-invasive mechanical ventilation)has become a key issue.Compared to other nebulization devices,using vibrating mesh nebulizers can effectively enhance the nebulization effect.For different types of respiratory support,the position of placing nebulization devices varies.For patients using high-flow nasal cannula,it is recommended to place the nebulizer at the inlet of the humidifier tank;for mechanically ventilated patients,the nebulizer should be placed 15 cm away from the ventilator or Y-tube,depending on the presence of basal airflow,to improve aerosol deposition in the lungs.However,most studies on nebulization effects are conducted in vitro.With future developments,aerosol inhalation therapy will be further standardized,providing patients with safer and more effective aerosol inhalation treatment.
Keywords：aerosolinhalation therapyaerosol depositionmechanical ventilationhigh-flow cannula
Publication Date：2024-12-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 989-994 )