Peri-pregnancy management of 21 hydroxylase deficiency
YANG Hai-yan
QIN Ying-fen
Abstract：The 21-hydroxylase deficiency(21-OHD)is the most common type of congenital adrenal hyperplasia.Although women with 21-OHD have declined fertility,they are still able to conceive.Both parties preparing for pregnancy should undergo genetic testing and consult genetic experts before pregnancy.If necessary,the methods such as in vitro fertilization and preimplantation genetic testing should be used to achieve optimal fertility.The 21-OHD women need to adjust glucocorticoids and mineralocorticoids before and during pregnancy,as well as on and after delivery,and postpartum,and should avoid adrenal crisis.We also have corresponding recommendations for monitoring indicators,prenatal diagnosis and treatment,and postpartum management during the perinatal period for 21-OHD female.The entire perinatal period requires experienced endocrinology,obstetrics,and genetic counseling experts to jointly manage.
Keywords：21-hydroxylase deficiencyfertilitypregnancyprenatal therapyglucocorticoid
Publication Date：2024-11-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 890-895 )