Relationship between dysfunction of the glymphatic system and long-term insomnia
HUANG Xiao-shan
ZHANG Hong-mei
BAO Lei
WANG Yu-qiao
WU Yun-cheng
ZHANG Shen-yang
Abstract：This study reviews the structure and function of the glymphatic system and its role in sleep and other neurological diseases.The glymphatic system,composed of astrocytes and perivascular spaces,is responsible for the exchange of interstitial fluid and cerebrospinal fluid,the clearance of metabolic waste from the brain,and the regulation of intracranial pressure.Sleep has a significant impact on the activity of the glymphatic system,with the highest clearance efficiency occurring during deep sleep.Research indicates that the glymphatic system plays a crucial role in waste clearance and regulation in neurological diseases such as Alzheimer's disease,Parkinson's disease,stroke,migraine,and epilepsy.Sleep significantly influences this system's clearance function,and sleep deprivation or disruption can lead to the accumulation of harmful proteins in the brain,exacerbating the development of neurological diseases.Studying the role of the glymphatic system in these diseases can help in understanding their pathogenesis and developing new therapeutic approaches.
Keywords：glymphatic systemsleep disorderdysfunction
Publication Date：2024-10-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 798-804 )