Association between osteocalcin level and pancreatic β-cell function in type 2 diabetes patients

ZHANG Meng; LIANG Lin-lang; TONG Hui-xin

doi:10.19538/j.nk2024080114

Abstract：Objective By investigating the correlation between serum osteocalcin(OC)level and the secretory function of pancreatic β cells in patients with type 2 diabetes mellitus,the role of bone metabolism and its products in the pathogenesis of diabetes mellitus is explored.Methods A total of 680 patients treated in General Hospital of Northern Theater Command from January 2018 to December 2022 were selected.All the patients were divided into four groups according to OC quartile level.Basic information and biochemical indexes of patients were collected in detail.All subjects underwent 75 g oral glucose tolerance test(OGTT)and insulin release test to detect islet function,and the hormone levels at all times,β cell function index(HOMA-β),area under the C-peptide curve in 180 minutes(AUCCP180),area under the glucose curve(AUCPG)and C-peptide secretion index were compared among the four groups.Correlation analysis was conducted by Pearson correlation analysis and linear regression after multi-factor correction.Results Through the comparative analysis of baseline data and hormone levels in different phases,it was shown that with the increase of OC level,insulin and C-peptide secretion in different phases of the four groups were observed to be on the rise,while blood glucose and glycosylated hemoglobin were on the decline.Pearson correlation analysis showed that Ln-OC was positively correlated with Ln-HOMA-β,Ln-AUCCP180 and Ln-C-peptide secretion index,and Ln-OC was negatively correlated with HbA1c and Ln-AUCPG(P＜0.05).The results of partial correlation analysis after adjusting for confounding factors were consistent with the above.Simple linear regression and multiple linear regression analysis results of Ln-HOMA-β and Ln-AUCPG as dependent variables showed:Ln-OC(β1=0.141,β2=0.113,β3=0.090;β1=-0.179,β2=-0.191,β3=-0.100),P＜0.05.Conclusions Serum osteocalcin level is correlated with islet beta cell function in patients with type 2 diabetes.Osteocalcin is a protective factor of islet beta cells,which can promote insulin secretion and improve islet function.