Association of genetic polymorphisms with type 2 diabetes susceptibility in part of the Karamay population
HU Yu-chen
ZHU Yu-jing
PENG Lin-rui
XIE Ai-xia
ZHENG Yi-ran
MAO Yu-qin
HAI Lin-na
ZHOU Ling
CHU Xiao-yan
ZHANG Yu-wei
Abstract：Objective To study the association between PNPLA3 rs738409,CDKAL1 rs7754840,GCKR rs780094 polymorphisms and T2DM susceptibility in different ethnicities of Karamay population in Xingjiang.Methods Our study was conducted in Karamay Integrated Chinese and Western Medicine Hospital(Municipal People's Hospital)in Xinjiang Province involving 236 diabetic patients and 371 healthy controls who visited the hospital from November 2021 to November 2022.Using the method of multiplex PCR technology and single-base extension technology for genotyping,we investigated the associations of SNPs with the incidence of T2DM and related clinical indicators in Han Chinese and minority ethnic groups from Xinjiang.Results Han Chinese with GG genotype of PNPLA3 rs738409 showed an increased risk of T2DM(Prec=0.013,OR=2.15,95％CI=1.18-3.92).It was also found that Han Chinese carriers with T allele of GCKR rs780094 were associated with reduced FPG levels(Pdom=0.021,β=-1.34,95％CI=-2.47--0.20)and higher TG levels(Prec=0.035,β=0.77,95％CI=0.06-1.48).While in minority ethnic groups,those who carried T allele of GCKR rs780094 were associated with higher HbA1c levels(Padd=0.001,β=0.71,95％CI=0.30-1.13;Pdom=0.001,β=0.96,95％CI=0.40-1.52)and lower BMI levels(Pdom=0.028,β=-2.34,95％CI=-4.43--0.26).Besides,CC genotype of CDKAL1 rs7754840 was significantly associated with reduced levels of HbA1c(Prec=0.001,β=-1.20,95％CI=-1.90--0.50)in minority ethnic groups.Conclusions The GG genotype at the PNPLA3 rs738409 locus is a risk factor for T2DM in the Han population of Xinjiang.Although no significant association was found between T2DM susceptibility and GCKR rs780094,CDKAL1 rs7754840 loci,variations at those two loci may also lead to changes in FPG,HbA1c,TG,and BMI levels in both Han Chinese and minority ethnic groups of Xinjiang.
Keywords：type 2 diabetessingle-nucleotide polymorphismHan Chineseethnic minorities
Publication Date：2024-08-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 653-658 )