Renal denervation for hypertension:anatomical and physiologic basis for selective ablation
LIU Hang
SUN Ying-xian
YIN Yue-hui
Abstract：Percutaneous renal denervation(RDN)can effectively lower blood pressure in a sustainable manner.Its clinical evidence is solid,but there are still problems such unstable effect of blood pressure reduction.In recent years,our comprehension of the neural regulation and physiological functions of the kidney has been progressively deepening,particularly,the existence of the renal parasympathetic nerve has been confirmed.The renal parasympathetic nerve exerts opposing functions on the sympathetic nerve,and the ablation-induced impairment of the renal parasympathetic nerve may contribute significantly to the unsatisfactory efficacy observed in current RDN procedures.Selective ablation guided by renal nerve stimulation holds great promise as a future development direction for RDN technology.
Keywords：percutaneous renal denervationrenal parasympathetic nerverenal nerve stimulationselective ablation
Publication Date：2024-08-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 645-648 )