Analysis of the muscle mass characteristics of CT images in patients on initial maintenance hemodialysis with cardiovascular disease
YUAN Li
CAO Jing-yuan
WANG Mei
WEI Kang
LIAO Xiao-pang
ZHANG Yi-ru
WANG Yao
YANG Ming
Abstract：Objective To assess the correlation between cardiovascular disease(CVD)and muscle mass in patients on initial maintenance hemodialysis(MHD).Methods A total of 116 patients on initial MHD from January 2014 to December 2019 at the Affiliated Hospital of Yangzhou University were included and divided into MHD with CVD group(62 cases)and MHD without CVD group(54 cases)according to their medical history and corresponding ancillary examinations.Clinical and imaging data were collected,and skeletal muscle density(SMD),skeletal muscle index(SMI),NAMA/TAMA index,and IMAT/TAMA index were calculated.The correlation between MHD combined with CVD and muscle mass-related indexes was analyzed and assessed.Results Compared with the MHD patients without CVD,the proportion of hypertension and diabetes,age,and blood uric acid level were higher in the MHD patients with CVD(all P＜0.05).In the MHD with CVD group,SMD(t=-3.104,P=0.002)and NAMA/TAMA index(t=-3.887,P＜0.001)were lower,while IMAT/TAMA index(z=-3.647,P＜0.001)was higher,but SMI(Z=-0.039,P=0.969)was not significantly different.After adjusting for confounders such as age,hypertension and diabetes,multivariate logistic regression analysis showed that low NAMA/TAMA index and low SMD were independently associated with the risk of MHD patients with CVD,and low IMAT/TAMA index was an independent protective factor of MHD patients with CVD.Conclusion MHD patients with CVD are prone to decreased muscle mass,and NAMA/TAMA index at the level of L1 transverse process measured by CT can be used to evaluate muscle mass in MHD patients,and is independently associated with MHD patients with CVD.
Keywords：myosteatosismaintenance hemodialysiscomputed tomographycardiovascular disease
Publication Date：2024-06-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 484-490 )