Health-related guality of life after left bundle branch area pacing upgrade in patients of chronic right ventricular pacing
WEI Ling-ling
YE Yang
SHENG Xia
FU Guo-sheng
JIANG Chen-yang
Abstract：Objevtive To determine the health-related quality of life(QOL)after left bundle branch area pacing(LBBAP)upgrade in patients after chronic long-term right ventricular pacing(RVP).Methods Patients(enrolled in the Sir Run Run Shaw Hospital from June,2020 to June,2022)referred for pulse generator change or heart failure with long-term RVP of larger than 40％attempted for LBBAP upgrade were included.Cardiovascular health and quality of life were measured by three sacles:36-Item Short-Form health survey(SF-36),Three-level version EQ-5D(EQ-5D-3L)and minnesota living with heart failure(MLHFQ).The datas were compared at baseline,3 months and 12 months after LBBAP.Results Permanent LBBAP upgrade was successful in 23 of twenty-five patients and were followed up for 12 months.After multi-time period statistical analysis,Improvements in QOL parameters including physical functioning(P＜0.001),role-physical(P＜0.001),general health(P＜0.001),vitality(P=0.005),Social role(P=0.006),and Mental health(P=0.002)on the MOS SF-36 Health Survey,Total scores of EQ-5D-3L(P=0.004)and MLHFQ(P＜0.001)were all improved significantly during 12 months,and the improvements were more obvious in 12 months than in 3 months.After 12-month follow up,Parameters of Cardiac function including:N-terminal pro-B-type(Pro-BNP)(P=0.004),left ventricular ejection fraction(LVEF)(P＜0.001)and left ventricular end of systolic volume(LVESV)(P=0.001)were all improvented significantly.Amony all patients,the improvement in QOL was greater in 11 patients(11/23)with pacing-induced cardiomyopathy(PICM)than those(12/23)withnot at 12-month follow-up.Conclusion The health-related QOL can be improved by LBBAP upgrade in patients by long term RVP.LBBAP can reverse electrical synchrony and structure remodeling by chronic RVP,patients with PICM benefit more.
Keywords：left bundle branch area pacingthe quality of liferight ventricular pacingpacing-induced cardiomyopathy
Publication Date：2024-05-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 403-408,414 )