Clinical analysis of BTK inhibitors combined with basic chemotherapy in newly diagnosed double expression diffused large B cell lymphoma
YANG Dan
LI Feng
YANG Fei-fei
ZHAO You-cai
XU Yan-li
ZHANG Xue-zhong
ZHANG Xiu-qun
Abstract：Objective To explore the clinical effect of BTK inhibitor combined with basic chemotherapy on newly diagnosed double-expressing diffuse large B-cell lymphoma(DLBCL).Methods Five cases of newly diagnosed MYC and BCL2 double-expressing DLBCL patients admitted to Nanjing First Hospital from November 2020 to March 2022 were retrospectively collected as research subjects.The patient's medical history is collected,and routine examinations,as well as PET-CT,bone marrow cell morphology,immunophenotyping,chromosomal detection and histological morphology,immunohistochemical examination,FISH and other specialized examinations are carried out.Results Five patients with MYC and BCL2 double-expressing DLBCL were initially diagnosed,of which 2 were high-grade B-cell lymphoma with not otherwise specified(HGBL,NOS),2 were CD5-positive double-expressing DLBCL patients.5 patients were given BTK-based combined chemotherapy,After three course of treatment,4 patients achieved CR,1 patient died after two course of treatment with central relapse,4 patients completed 6 courses of combination therapy and 2 courses of consolidation therapy,1 patient received autologous hematopoietic stem cell transplantation,all patients received intrathecal injection to prevent central invasion during treatment.As of October 2023,the median follow-up time was 31 months,and all 4 patients were in complete remission.Conclusion DLBCL patients with double expression of MYC and BCL2 were treated with BTK inhibitor combined with basic chemotherapy has a good effect and the safety is high,but the sample size needs to be expanded for further exploration in the later stage.
Keywords：diffuse large B-cell lymphomadouble-expressingBTK inhibitor
Publication Date：2024-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 42-48 )