Predictive value of peripheral systolic blood pressure and pulse pressure for new-onset carotid plaque in community population

WANG Shi-xuan; SUN Peng-fei; FAN Fang-fang; JIA Jia; YANG Ying; GAO Lan; HAN Xiao-ning; CHENG Guan-liang; ZHANG Yan; HUO Yong

doi:10.19538/j.nk2018050113

Abstract：Objective To investigate the predictive value of peripheral systolic blood pressure (SBP) and pulse pressure (PP) for new-onset carotid plaque in a Chinese community-based population. Methods A total of 748 participants without carotid plaque at baseline from an atherosclerosis cohort with 2.30-year follow-up in Beijing, China, were included in our analysis. The inclusion criteria were: complrtr data, no carotid plaque at baseline, completing the follow-up of 2004. Logistic regression models were used to examine the association between SBP, PP and new-onset carotid plaque. Results Subjects were averagedly (51.5±4.9) years old, and 28.0％ (n=213) were male; 34.7％ (n=264) had hypertension, 15.4％ (n=117) had diabetes, and 67.2％ (n=511) had dyslipidemia. After a median of 2.30 years of follow-up, new-onset carotid plaque ratio was 30.9％ (n=235). Every 10 mmHg increase of SBP and PP was associated with 14％ and 27％ increase of carotid plaque after adjustment for gender, age, body mass index, eGFR, current smoking and drinking status, dyslipidemia, diabetes mellitus, lipid-lowering medications and hypoglycemic medications. When SBP and PP were forced into the model simultaneously, only PP showed significant correlation with new-onset plaque (for per 10mmHg increase of PP, OR=1.27, 95％ CI 1.00-1.62; for per 10 mmHg increase of SBP, OR=0.99, 95％ CI 0.83-1.19). Subgroup analysis showed that compared with the lowest tertile group, PP in the highest tertile group had significant higher risk of new-onset carotid plaque. Conclusion Both SBP and PP are associated with increased risk of new-onset carotid plaque, whereas the predictive value of PP for new-onset carotid plaque is better than SBP.