Comparison of cyclosporine A with corticosteroids in the treatment of adult patients with acquired pure red cell aplasia
WU Xue-mei
LU Xing-yu
HE Yao
WANG Su-li
SHEN Wen-yi
QIAO Chun
WU Yu-jie
LU Rui-nan
WANG Shuai
ZHANG Jian-fu
HONG Ming
ZHU Yu
LI Jian-yong
HE Guang-sheng
Abstract：Objective To assess the effect of cyclosporine A (CsA) and corticosteroids (CS) in the treatment of adult patients with acquired pure red cell aplasia (PRCA). Methods Clinical data of 42 cases receiving cyclosporine A (CsA), and/or corticosteroids (CS), or other immunosuppressive agents were retrospectively analyzed, including CsA (n=16), CS (n=13), CsA in combination with CS (n=6), or other immunosuppressive agents (n=4). Results The initial response rates were similar among these patients (75.0％, 46.2％, 66.7％, 75.0％, P=0.456). The cumulative response rates in patients receiving CsA, CS, CsA in combination with CS, or other immunosuppressive agents were 69.6％ (16/23), 50.0％ (7/14), 71.4％ (5/7), 42.9％ (6/14), respectively (P=0.376); the cumulative rates of CR were 26.1％ (6/23), 28.6％ (4/14), 57.1％ (4/7), 14.3％ (2/14), respectively (P=0.284). In 27 refractory and relapsed PRCA patients, 11 out of 17 patients (64.7％) achieved remission by CsA and/or CS regimen, while 3 of 10 patients (30.0％) responded to other immunosuppressive agents (P=0.120). Conclusion CsA and/or CS are similarly effective in treating PRCA. For patients with relapse or refractory PRCA, there are no satisfactory treatments if CsA and/or CS fail.
Keywords：anemiaaplasiared cellcyclosporine Acorticosteroids
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 455-458 )