An evaluation on reliability, validity and responsiveness of the revised edition of Asthma Control Questionnaire for patients with chest tightness variant asthma
LIN Shi-hua
CAO Yuan
ZHU Ding
MAO Yan-xiong
ZHANG Chao
LI Wen
SHEN Hua-hao
Abstract：Objective To evaluate the clinical validity, reliability and responsiveness of the revised edition of Asthma Control Questionnaire (r-ACQ). Methods Patients diagnosed with chest tightness variant asthma (CTVA) were randomly enrolled from the Second Affiliated Hospital of Zhejiang University School of Medicine from May 2015 to December 2016. All participants completed the r-ACQ, the Asthma Quality of Life Questionnaire (AQLQ) and the MOS item short from health survey (SF-36) at enrollment. A month later, participants were reevaluated by the r-ACQ and the Global Rating of Change (GRC) at follow-up visits. Results Finally, 66 patients were enrolled. The correlation coefficient between the r-ACQ and AQLQ (n=66) was -0.706 (P<0.001). The r-ACQ scores were also associated with several dimensions of the SF-36 (n=43), including the Role Physical (r=-0.655, P<0.001), the Social Function (r=-0.453, P=0.002) and the Vitality (r=-0.407, P=0.007) dimension. The Cronbach's alpha coefficient of all items in r-ACQ was 0.632. The intra-class correlation coefficient was 0.959 (95％ confidence interval, 0.891～0.985) among patients in stable condition (n=18). Scores of r-ACQ in patients with obvious improvement in chest tightness (n=23) significantly decreased after a month (Z= -4.026, P<0.001). Conclusion The r-ACQ shows excellent clinical validity, reliability and responsiveness, thus being appropriate for symptom control assessment in CTVA patients.
Keywords：the revised editionasthma control questionnairechest tightness variant asthmareliabilityvalidity
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 451-454 )