High salt intake exacerbates cardic damage in hypertensive and diabetic patients.
YANG Song
LI Qiang
CHANG Le
LI Ying-sha
SUN fang
LIU Dao-yan
ZHU Zhi-ming
ZHAO Zhi-gang
Abstract：Objective To study the effect of high salt diet on cardiac damage in 500 hypertensive patients with diabetes mellitus. Methods 24-hour urinary biochemical index, glycosylated hemoglobin(HbA1c),interventricular septal thickness(IVST),left ventricular mass index(LVMI) and general information were collected in 500 patients with hypertension and type 2 diabetes mellitus. Daily sodium intake was derived from 24-hour urinary sodium excretion.To analyze the correlation between salt intake and blood glucose status and left ventricular hypertrophy,and to compare the difference of left ventricular hypertrophy under different salt intake and blood glucose state. Results All hypertensive and diabetic patients'IVST and LVMI were positively correlated with salt intake(P<0.0001),which were not significant correlated with glycosylated hemoglobin(P>0.05).In the high-salt group, regardless of the level of blood glucose, patients'blood pressure there was no significant difference or significantly lower than the low salt and normal blood glucose in patients,but their IVST and LVMI were significantly higher than the low salt and normal blood glucose in patients(P<0.05). Conclution With the aggravation of salt intake in hypertensive with diabetic patients,their cardiac remodeling are more significant,and this effect of high salt is independent of blood pressure levels.Blood glucose control is relatively stable, high salt intake will offset the cardiogenic benefits of hypoglycemia.
Keywords：hypertensiondiabeteshigh salt intakecardic demage
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 370-372 )