Clinical analysis of the relationship between low serum IgG level and ulcerative colitis.
WANG Zheng
ZHENG Wei-yang
LI Ji
TAN Bei
SHU Hui-jun
LYU Hong
LI Yue
QIAN Jia-ming
YANG Hong
Abstract：Objective To investigate the relationship between low serum immunoglobulin G (IgG) and ulcerative colitis (UC). Methods A total of 73 cases of UC in Peking Union Medical College Hospital from January 2010 to June 2017 were enrolled, and the clinical data of patients with low serum IgG and normal serum IgG were comparatively analyzed retrospectively. Results Twelve (16. 4％) of 73 patients with UC had low serum IgG. Compared with pa tients with normal serum IgG, the level of high-sensitivity C-reactive protein (hsCRP) was significantly higher and severe cases were obviously more in those patients with low serum IgG [(47. 82±29. 89)mg/L vs (32. 89±36. 45)mg/L, P=0. 048 and 100％ vs 31. 1％, P<0. 0001]. In terms of concurrent infection, cytomegalovirus(CMV) infection was more frequent in UC patients with low serum IgG(61. 5％ vs 27. 8％, P=0. 018). The effective rate after corticosteroid therapy in low serum IgG group was dramatically lower than that in normal serum IgG group (16. 7％ vs 69. 8％, P=0. 002). The sensitivity and specificity of predicting corticosteroid effectiveness by ROC curve was 97. 4％ and 41. 2％ at cut-off value of 6. 73 g/L for IgG. Conclution Serum IgG level may serve as a promising clinical indicator to predict the disease severity and effectiveness of corticosteroid treatment in the patients with UC.
Keywords：ulcerative colitisserum IgGcytomegalovirusinfectioncorticosteroid
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 227-230 )