Progress of diagnosis and treatment for chronic neutrophilic leukemia
GONG Zi-mu
Shimin HU
Abstract：Chronic neutrophilic leukemia (CNL) is a rare but potentially life-threatening chronic myeloproliferative neoplasm manifested by leukocytosis exceeding 25× 109/L,predominantly neutrophils,without increased blast percentage,dysplasia or evidence of other myeloproliferative disorders or physiological neutrophilia.CSF3R T618I,a somatic activating mutation of the CSF3R gene,plays a significant role in the pathogenesis of CNL and has been recognized as a diagnostic marker for CNL recently.Concurrent mutations of SETBP1 and ASXL1 also appear to be associated with prognosis and response to treatment.In the era of individualized treatment,the goal of CNL management should be based on both clinical features and molecular and biological profile.
Keywords：chronic neutrophilic leukemiamyeloproliferative neoplasm
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 123-126 )