Correlation between subclinical hypothyroidism and diabetic nephropathy in the patients with type 2 diabetes mellitus
CHEN Xiao-lei
JIA Nong
KE Ting-yu
TIAN Lin-yu
CAI Li-ping
YANG Lin
SONG Lin
YANG Yue-lin
YIN Jian-hui
Abstract：Objective To investigate the correlation of subclinical hypothyroidism (SCH) with diabetic nephropathy (DKD) and its possible mechanism.Methods Total 337 T2DM patients,154 with SCH and 183 without SCH as control group.SPSS17.0 statistical software is used for statistical analysis.Results SCH positive group had statistical difference in the index of eGFR SUA CYSC compared with control group(P＜0.05).After correction of age factor,duration,BMI and HbA1c,there was a positive correlation between TSH and CYSC(r=0.291,P＜0.01).Multivariate unconditional Logistic regression indicated that elevated thyroid stimulating hormone levels (TSH) were independent risk factors for diabetic nephropathy (OR 1.14,95％CI 1.04-1.22,P＜0.05).Conclution There is a correlation between subclinical hypothyroidism and diabetic nephropathy and may contribute to the development of diabetic nephropathy.
Keywords：type 2 diabetes mellitussubclinical hypothyroidismtype 2 diabetic nephropathyuric acidcystatin C
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 65-68 )