Prenatal serological and virological characteristics of pregnant women with chronic HBV infection in community population
WEI Kai-ping
LU Ying
YAN Ling
LIU Jian-xun
ZHAI Xiang-jun
CHANG Zhan-jun
ZHU Feng-cai
LI Rong-cheng
LI Yan-ping
ZHANG Xin
LIU Zhi-xiu
XIAO Yi-wei
LI Jie
Abstract：Objective To investigate the prenatal serological and virological characteristics of HBsAg-positive pregnant women without in some areas in China.Methods A total of 1741 HBsAg-positive pregnant women were recruited from Guangxi,Jiangsu and Henan provinces.Serum samples were collected before labor for evaluation of pre-delivery ALT,HBV serological markers and HBV DNA.HBsAg,HBeAg and HBV DNA levels were tested by Abbott Architect i2000 and m2000 systems,respectively.HBV genotyping was performed by a method based on nested polymerase chain reaction (nPCR) established in our lab.Results Among 1741 HBsAgpositive women,37.0％(645/1741) were HBeAg positive and 63.0％(1096/1741) were HBeAg negative,respectively.The median titers of HBsAg,HBV DNA levels and the proportion of genotype B in HBeAg-positive women were higher than those of HBeAg-negative women,but the age of HBeAg-positive women was younger than that of HBeAg-negative ones.The proportion of HBeAg-positive women was gradually declining with the increase of age.HBsAg titers and HBeAg titers were positively correlated with HBV DNA levels in HBeAg-positive group (r=0.790,P＜0.001;r=0.564,P＜0.001).However,there was no correlation between HBsAg titers and HBV DNA levels in HBeAg-negative group (r=0.020,P=0.517).Conclusion The serological and virological characteristics of treatmentnaive HBsAg-positive women differed by the HBeAg status.Quantitative HBsAg titer and HBeAg titer might be surrogate markers for HBV DNA levels in HBeAg-positive women.
Keywords：hepatits B viruspregnant womenHBsAgHBeAgHBV DNA
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1074-1078 )