The influence of glucose metabolism and its mechanism in patients with thyroid associated ophthalmopathy treated with high-dose glucocorticoid
SUN Zheng
TANG Wei
SUN Liang-liang
LI Tuo
NI Qi
LU Xiao-min
XIA Xiao-ling
SHI Yong-quan
Abstract：Objective To observe the incidence of impaired glucose regulation after intravenous methylprednisolone (IVMP) treatment in patients with thyroid-associated ophthalmopathy(TAO) and to explore the possible mechanisms of hypoglycemia.Methods Totally 90 patients with TAO were enrolled in this study.The changes of blood glucose were observed under the different cumulative dose of GCs.Results (1) The incidence of FPG abnormality was 1.11％ after IVMP treatment in TAO patients,and the blood glucose level did not increase with the cumulative dose of GCs(r=-0.080,P=0.452).In the 22 patients under OGTT test,27.27％ of TAO patients had abnormal glucose tolerance after treatment with IVMP,and the blood glucose level did not increase with the cumulative dose of GCs(r=--0.296,P=0.181);(2)There were obvious decreases in CISI and OGSI of the HBG group (compared with NBG group,P＜0.05).Compared with the NBG group,the early phase secretion (DI0) and late phase (DI120,DI180) in HBG were declined sharply (P＜0.05).Conclution IVMP treatment in TAO patients can cause elevated blood glucose,but has nothing to do with the cumulative dose of G Cs.lhe mechanism of elevated blood glucose may mainly be pancreatic β-cell reserve dysfunction.
Keywords：thyroid-associated ophthalmopathyblood glucosemethylprednisoloneinsulin resistanceislet β-cell function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 903-907 )