Clinical phenotype and hemodynamic characteristics of patients with different subtypes of pulmonary arterial hypertension in central China
YANG Kai-yue
ZHANG Lian-sheng
ZHOU Hong-mei
LI Shan-shan
ZHANG Gang-cheng
ZHENG Xuan
Abstract：Objective To analyze clinical phenotypes and hemodynamic characteristics of patients with different subtypes of pulmonary artedal hypertension (PAH)and to improve clinical diagnosis and treatment.Methods From January 2005 to April 2017,556 patients with idiopathic pulmonary arterial hypertension,heritable pulmonary arterial hypertension,and accociated pulmonary arterial hypertension (connective tissue disease,portal hypertension and congenital heart disease)were enrolled at Wuhan Asia Heart Hospital.Clinical phenotypes and hemodynamic characteristics were compared among different subtypes groups of PAH.Results Among the 556 cases,there were 367 (66.0％)female and the median age was 28.2 yars.CHD-PAH group (448 cases)had the significantly higher mPAP (F=7.319,P=0.001).Compared with other groups,NT-proBNP of CHD-PAH group was relatively lower (F=5.960,P=0.003).IPAH group had higher ALT (F=5.833,P=0.007),USA (F=6.659,P=0.001) and NT-proBNP (F=4.199,P=0.027).Moreover,therewasahighpercentageofcardiacfunctionalclassⅢ/IⅣ(44.4％)inIPAHgroup(x2=23.099,P=0.001).Conclution Patients with pulmonary arterial hypertension in central China are younger and frequently in female than in previous descriptions.CHD-PAH is the most common type.NT-proBNP is not parallel to mPAP.The liver function and kidney function in IPAH ptients are damaged and they are already at the severe condition when seeing doctor for the first time.
Keywords：pulmonary arterial hypertensionclinical phenotypehemodynamics
Publication Date：2017-01-01
Pages：5( 898-902 )