Challenges in screening tests of primary aldosteronism
ZHAO Lin
LI Xiao-ying
Abstract：Primary aldosteronism (PA) is recognized as the most frequent cause of endocrine hypertension,and also the most frequent cause of secondary hypertension.PA is often unrecognized and is associated with a high rate of cardiovascular and cerebrovascular complications.PA prevalence rate is more than 5％,affecting overl0％ of the general hypertensive population and even20 ％ of refractorypopulation.All hypertension patients should be carefully screened for PA.Screening with aldosterone-to-renin ratio (ARR) is advocated as the most reliable tool to screen for PA.The different analytical methods have a great influence on the ARR ratio.Subsequent confirmatory tests are:oral salt loading,fludrocortisone suppression test,saline infusion test and captopril challenge test.Individual laboratories should select an cut-offvalue (for their combination of renin and aldosterone methods) that is based on validation in their local population.
Keywords：primary aldosteronismscreening testsaldosterone-to-renin ratioliquid chromatography-mass spectrometric method
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 881-884 )