Effect of different administration regimens of antiplatelet treatment on stent thrombosis and gastrointestinal bleeding events after transjugular intrahepatic portosystemic shunt procedure
CHEN Meng-jun
WU Jian-sheng
DONG Le-mei
JIN Yin
HUANG Zhi-ming
WU Wei
Abstract：Objective To study the effect of different administration regimens of antiplatelet treatment on stent thrombosis and gastrointestinal bleeding events after transjugular intrahepatic portosystemic shunt procedure.Methods We measured thrombin generation by ultrasonography and liver function in the experimental group (n=30) using aspirin and clopidogrel within 1 year after TIPS procedure and compared the results with control group (n=30) using clopidogrel.Meantime,all gastrointestinal bleeding events were recorded.Results (1) At the end of the followed-up period,1 patient developed portal vein stents thrombosis (PVST) in the clopidogrel group,compared with 2 in the control group (P＞0.05);(2)Gastrointestinal bleeding events occured in 9 patients in the experimental group,compared with 2 in the control group procedure.Conclusion The use of aspirin and clopidogrel therapy can't reduce the presence of stents thrombotic events but has more gastrointestinal bleeding events.It's recommended that,clopidogrel be safely administered to cirrhotic patients after TIPS.
Keywords：esophageal and gastric varicesplatelet aggregation inhibitorstransjugular intrahepatic portosystemic shuntcirrhosisgastrointestinal bleeding events
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 826-829 )