Pathological features and diagnosis of C3 glomerulopathy
ZENG Cai-hong
Abstract：C3 glomerulopathy is resulting from abnormal control of the complement altemative pathway due to genetic and acquired complement abnormalities.Renal biopsy shows C3 in glomeruli on immunofluorescence,but there is no Clq or C4,and there is minimal or no immunoglobulin.On the basis of electron microscopy, C3 glomerulopathy is divided into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN).The morphology seen by light microscopy is variable and includes membranoproliferative pattern,endocapillary proliferation,mesangial proliferation,and crescentic glomerulonephritis.The diagnosis of C3 glomerulopathy dependS on renal biopsy.A biochemical evaluation of the AP,determination of autoantibodies,a comprehensive genetic screening,and testing for a plasma cell disorder should be considered.
Keywords：C3 glomerulopathydense deposit diseaseC3 glomerulonephritispathology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 781-785 )