Clinical analysis of hallucinations in patients with Parkinson's disease

LI Chun-yu; OU Ru-wei; LIU Hui; HOU Yan-bing; WEI Qian-qian; CAO Bei; SONG Wei; ZHAO Bi; SHANG Hui-fang

doi:10.19538/j.nk2017080114

Abstract：Objective To explore the prevalence and clinical factors of hallucination in patients with Parkinson's disease (PD).Methods A cross-sectional analysis of 518 patients with PD was included.Unified PD Rating Scale (UPDRS),Non-Motor Symptoms Scale (NMSS),Hamilton Depression Scale (HAMD),Hamilton Anxiety Scale (HAMA),Frontal Assessment Battery (FAB),and Montreal Cognitive Assessment (MoCA) were used to assess the motor and non-motor symptoms.PD Questionnaire-39 (PDQ-39) was applied to assess the QoL.The patients were divided into two groups:with-hallucination group and without-hallucination group.Compare the statistical information,clinical data and the scores of those scales,and make a multivariate analysis.Results Fortynine PD patients (9.5％) reported hallucinations.Patients with hallucinations had older age,longer disease duration,higher levodopa equivalent daily doses,higher prevalence of dopamine receptor agonist use,higher incidences of motor fluctuation and dyskinesia,higher media H&Y degree,higher scores for the UPDRS part Ⅲ,NMSS,HAMD,HAMA and PDQ-39 than patient without hallucinations (P＜0.05).After the related factors were adjusted,the NMSS score,HAMD score and PDQ-39 score were significantly higher in withhallucination group than in without-hallucination group(P＜0.05),whereas the FAB and MoCA scores were not different between the two groups.The binary logistic regression analysis indicated that disease duration (OR=1.142,P＜0.001),urinary symptoms score in NMSS (OR=1.058,P=0.001),and HAMA score (OR=1.058,P=0.009) were associated with the presence of hallucinations in PD patients.Conclusions Hallucinations are not rare in PD patients,which may decrease the QoL of PD patients.Patients with longer disease duration,more severe urinary symptoms and anxiety are likely to experience hallucinations.