Analysis of paraquat elimination by hemoperfusion combined with hemodiafiltration or continuous veno-venous hemofiltration on acute paraquat poisoning
ZHAO Shuang
LI Xin-hua
FAN Shu-ling
HU Da-yong
LI Chang-bin
XUE Wen
PENG Ai
Abstract：Objective To explore the paraquat(PQ) elimination by combining two blood purification methods,HP+HDF and HP+CVVH,in acute PQpoisoning.Method Sixteen patients with acute PQpoisoning were enrolled in this research,who were treated from August 2013 to December 2015 in Shanghai Tenth People's Hospital.The patients were divided into HP+HDF group (n=7) and HP+CVVH group (n=9).The concentrations of PQin serum and urine samples were compared between the two groups.The liver and kidney functions at 3 days and 7 days were also compared.Results (1)The serum level of PQwas significantly decreased in both groups (P＜0.01).(2)The extraction rate and clearance rate of PQin HP+HDF group were higher than that of HP+CVVH group (P＜0.05).(3)In the HP+HDF group,the serum concentration of PQwas reduced in the first 2 hours,but serum concentration of PQin 3 patients was elevated.On the contrary,in the HP+CVVH group,the serum concentration of PQwas reduced in the first 12 hours,and maintained at low level till the end of the blood purification.(4)After the blood purification,the serum concentration of PQwas reduced significantly in the HP+CVVH group(P＜0.01),but not in the HP+HDF group (P＞0.05);the PQconcentration of urine was reduced significantly in both groups;PQreduction percentage of both serum and urine in HP+CVVH group was higher than that in HP+HDF group (P＜0.01).(5)The serum level of ALT,AST,SCr and BUN in HP+CVVH group on 7th day was lower than on 3rd day(P＜0.05).Conclusion Both blood purification methods can eliminate PQfrom blood,and reduce POconcentration of urine;the HP+CVVH method can eliminate PQmore efficiently and smoothly,avoiding its rebound.The present study provids detailed data for the treatment of acute PQpoisoning using HP+HDF and HP+CVVH technologies.
Keywords：paraquat poisoninghemoperfusionhemodiafiltrationcontinuous veno-venous hemofiltration
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 621-625 )