Tripterygium wilfordii Hook F combined with angiotensin receptor blocker in the treatment of IgA nephropathy with moderate proteinuria
ZHU Lin-bo
WANG Juan
LIU Lin-lin
YAO Li
LI Zi-long
LI Yan-qiu
FAN Qiu-ling
WANG Li-ning
Abstract：Objective To compare the efficacy of tripterygium wilfordii Hook F (TwHF) combined with angiotensin receptor blocker (ARB) with that of only ARB in the treatment of IgA nehropathy with moderate proteinuria.Methods We included the patients with primary IgA nephropathy hospitalized in our hospital between Jan.2014 and Dec.2015,who had urinary protein excretions of 1-3.5g/d and normal renal function.Thirty patients were treated with TwHF combined with ARB,and we included randomly 30 patients treated with only ARB in the same period.The clinical parameters before and after treatment were compared within the groups,and the rates of clinical remission were compared between the two groups.Results The baseline clinical and pathological characteristics were not significantly different between the two groups.After 6-month treatment,the urinary protein excretion and serum albunin were improved significantly in the two groups (P values ＜0.05),and renal function remained stable.The rate of clinical remission in the combination group was significantly higher than with only ARB (P ＜ 0.05).Conclusions TwHF combined with ARB can reduce urinary protein excretion,improve the levels of serum albumin,and stabilize renal function in IgA nephropathy patients with moderate proteinuria.
Keywords：tripterygium wilfordii Hook Fangiotensin receptor blockerIgA nephropathy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 549-551 )