The effect of different sampling time on dual-plasma-sample method in determination of iohexol clearance
ZHANG Yong
LI Tai-feng
FENG Wan-yu
WANG Yan
YANG Bing
WANG Mi
YU Ze
SUI Zhun
ZUO Li
Abstract：Objective Compare the effect of different sampling time on dual-plasma-sample method in determination of iohexol clearance to find the optimal sampling time of DPSM.Methods 40 healthy volunteers and 78 patients with kidney disease were enrolled,blood samples were drawn after a single-injection of5mL iohexol at 2 h,3 h and 4 h.Iohexol concentration was detected by HPLC to calculate GFR.The agreement and accuracy between DPSM-GFRs and MPSM-GFR were compared.Results The agreement between GFR23,GFR34,GFR24 and MPSM-GFR were 0.990,0.971,0.999 respectively,mean difference were (-0.95±4.76)mL/(min·1.73m2),(0.39±8.94)mL/(min·1.73m2),(-0.59±1.65)mL/(min·1.73m2) respectively.Correlation The sampling time of DPSM at 2 h and 4 h showed the best agreement and accuracy with MPSM-GFR.
Keywords：glomerular filtration rateiohexolplasma clearancehigh performance liquid chromatography
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 540-543 )