Clinical characteristics and strategies of diagnosis and treatment of renal involvement in primary Sj(o)gren's syndrome
ZHENG Hui
YANG Cheng-de
Abstract：Primary Sj(o)gren's syndrome (pSS) is an autoimmune disease that mainly affects the exocrine glands and results in sicca symptoms (dryness of the eyes and mouth).Systemic complications can occur in pSS,but renal involvement is rare.The most frequent form of nephropathy in pSS is tubulointerstitial nephritis (TIN) and membranoproliferative glomerulonephritis (MPGN) secondary to cryoglobulinaemia.The combination of steroids,immunosuppressants or rituximab,plasma exchange can be used as the treatment choice in MPGN secondary to cryoglobulinaemia.For patients with TIN,steroid therapy (≥0.5 mg/kg per day) is an efficient option.The value ofimmunosuppressants or rituximab in the treatment of TIN is still in debate.
Keywords：Sj(o)gren syndromenephropathytubulointerstitial nephritismembrane proliferative glomerulonephritis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 499-502 )