Liver damage in Sj(o)gren's syndrome
CHEN Huan-xue
WANG Xiao-fei
Abstract：Sj(o)gren's syndrome (SS) is a connective tissue disease characterized by the invasion to lacrimal glands and salivary glands.Liver damage is one of the common complications.There are many causes and it is generally believed that the pathogenesis is due to the infiltration of lymphocytes and plasmocyte to the hepatic portal,which leads to humoral and cellular immune abnormalities,releasing a variety of inflammatory mediators to cause tissue inflammation and destruction.Clinical manifestations are not specific.SS is closely related to autoimmune liver disease,but there is no unified conclusion about these two kinds of liver damage at present.Corticosteroids can quickly improve clinical symptoms and laboratory results.Immunosuppressant can be used in patients with rapid progression.Few studies have been done on the effects of rituximab on SS liver damage.Ursodeoxycholic acid is commonly used in the treatment of SS complicated with primary biliary cirrhosis.
Keywords：Sj(o)gren's syndromeliver damageprimary biliary cirrhosisautoimmune hepatitis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 496-498 )