DOI: 10.7504/nk2015020407
Clinical characteristics and analysis of the rheumatoid arthritis-associated interstitial lung disease
DAI Bing-bing
YANG Ping-ting
LIU Chang
LEI Lei
ZHANG Hao
Abstract：Objective To investigate the clinical characteristics of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).Methods A total of 171 RA patients were classified as 2 groups:without RA group (RA-no ILD,n =145) and the RA-ILD (n =26) group,and their clinical and laboratory data were analyzed retrospectively.Results The incidence of RA-ILD was 15.2％.The patients with RA-ILD had older age,longer disease duration and higher DAS28 scores than the RA patients without ILD (P＜0.05).A proportion of 57.7％ RA-ILD patients were asymptomatic at the onset of the diseases.Higher levels of erythrocyte sedimentation rate (ESR),C-reactive protein(CRP),rheumatoid factor (RF) as well as anti-cyclic citrullinated peptide(anti-CCP) antibodies were found in the RA-ILD group than in the RA-no ILD group (P＜0.05).Multivariable analysis indicated that the correlative risk factors of RA-ILD were age and RF levels.Conclusion The presence ofILD is a common complication of RA and positive correlation exists between ILD and high disease activity of RA.Both of age and increased RF levels are risk factors.
Keywords：rheumatoid arthritisinterstitial lung disease
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)