Association between peripheral neutrophil count and pulse wave velocity

doi:10.7504/nk2015020405

Abstract：Objective To investigate the relationship between peripheral neutrophil count and pulse wave velocity (PWV) in a middle-aged and elderly Chinese population.Methods Tbis cross-sectional study included 2395 middle-aged and elderly subjects from Shanghai,China.PWV were determined by baPWV.Results The peripheral neutrophil count levels in all subjects were positively correlated with PWV (r =17.71,P＜0.0001) after being adjusted for age,gender,body mass index (BMI),systolic blood pressure (SBP),high-density lipoprotein (HDL),low-density lipoprotein (LDL),triglyceride (TG),total cholesterol (TC) level and oral glucose tolerance test (OGTT)-2 h plasma glucose (2h-PG).A logistic regression analysis,adjusted for age,sex,BMI,2h-PG,LDL,HDL,TG,TC,revealed that compared with the lowest quartile of the neutrophil count,the highest quartile were significantly associated with the risk of arteriosclerosis (adjusted OR =1.39,95％CI 1.02-1.88,P＜ 0.05).But after adjustment for SBP,the association was not significant.Conclusion In a middle-aged and elderly Chinese population,the elevated neutrophil count level is associated with ateriosclerosis after adjustments of conventional cardiovascular risk factors,but the result is not independent of SBP,implying that neutrophil count might be an independent factor of arteriosclerosis.