DOI: 10.7504/nk2015020401
Application of computed tomography in prediction of portal pressure in hepatitis B associated cirrhosis
YAN Shi-ping
WU Hao
WANG Guang-chuan
ZHU Qiang
Abstract：Objective To find an accurate and effective non-invasive method to predict the value of hepatic venous pressure gradient (HVPG).Methods A total of 75 cirrhotic patients with hepatitis B were enrolled.All patients underwent computed tomography (CT),transjugular HVPG measurement,liver function test,prothrombin time (PT) recording and platelet counting.Liver and spleen volumes,the internal diameters of portal and splenic veins,and the presence of ascites were measured by CT.The Child-Pugh score for each patient was calculated.We assessed the ability of all variables to predict HVPG values.The variables with the highest ability to predict the HVPG value were applied to construct a model to predict HVPG＞ 12mmHg.Results The predictive model with liver/spleen volume ratio was constructed for predicting HVPG values.The following equation was:HVPG score =18.912-7.173 × ln(liver/spleen volume).The values of sensitivity,specificity,positive and negative predictive value of the equation were 92.9％,79.2％,83.9％ and 90.5％ respectively.The area under the curve (AUC) of this predictive equation was 0.906.Conclusions Liver/spleen volume ratio can accurately predict HVPG value in patients with hepatitis B associated cirrhosis.
Keywords：liver cirrhosisvariceal hemorrhagehvpg predict modelliver/spleen volume ratio
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)