Henoch-Sch(o)nlein nephritis in adults:outcome and prognostic factors

LI Yue-ting; CHEN Jin-hai; HUANG Rong-gui

doi:10.7504/nk2014050503

Abstract：Objective To evaluate the clinical outcomes and risk factors in adult patients with Henoch-Sch(o)nlein nephritis (HSPN).Methods A total of 76 adult patients with HSPN were enrolled in this study.They were followed up for 22 to 119 months,and the data of their clinical manifestations,renal pathological findings and outcomes were collected.Renal pathological changes were semi-quantitatively graded.Results Ten patients (13.2％) progressed to end-stage renal failure (ESRD).On univariate analysis,factors predicting ESRD were hypertension and renal impairment at presentation,proteinuria ≥ 1.0 g/d during following-up,and the tubulointerstitial chronicity ; after the adjustment,multivariate analysis indicated the following parameters as independent prognostic predictors:renal impairment at presentation (OR =10.96,95％ CI 1.56-77.26,P ＜ 0.05) and the tubulointerstitial chronicity index (OR =2.77,95 ％ CI 1.20-6.39,P ＜ 0.05).No data detected at presentation,including age,sex,macroscopic hematuria,proteinuria ≥ 1.0 g/d,glomerular activity index and chronicity index were significantly related to ESRD.Conclusion Renal impairment at presentation and the tubulointerstitial chronicity index are risk factors for ESRD.