Analysis of MEN1 gene in two cases of multiple endocrine neoplasia type 1
LI Zhi-dan
SHAN Zhong-yan
TENG Wei-ping
LI Jia
LU Li
SHAN Ling
YU Jia-shu
FAN Chen-ling
WANG Hong
GUO Rui
ZHANG Hong-mei
Abstract：Objectlve To study the MEN1 gene mutation in two cases of multiple endocrine neoplasia type 1.Methods Genomic DNA was extracted from the peripheral blood lymphocytes of patients.PCR was performed to amplify 9 exons of MEN1 gene.The PCR products were directly sequenced.Results A heterozygote C to T teansition was detected in c.1378 within exon 10 in one patient;No mutation was found in the entire MEN1 gene coding region of the other patient.Conclusion The mutation of c.1378C＞T(Arg460Ter) in MEN1 gene is one type of MEN gene mutations in China.
Keywords：multiple endocrine neoplasia type 1MEN1 gene
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 343-345,后插2 )