Relationship between parathyroid hormone level and central arterial stiffness in patients with high risk of coronary artery disease and preserved renal function
YAN Zi-jun
ZHANG Rui-yan
ZUO Jun-li
CHU Shao-li
SUN Wei-qian
Abstract：Objective To study the relationship between parathyroid hormone(PTH) level and central arterial stiffness in patients with high risk of coronary artery disease(CAD) and preserved renal function. Methods Seventy-seven patients with at least one risk factor of coronary artery disease (CAD) were divided into increased arterial stiffness group(n = 35) and control group(n = 42), based on whether the noninvasive pulse wave analysis index of the central pulse pressure (CPP) was higher than 40mmHg or not. Coronary artery angiography was performed in all cases. Serum intact PTH, calcium, phosphor, and highly sensitive C reactive protein (hsCRP) was assessed by radioimmunoassay. Coronary angiography was also performed. Results The patients in increased arterial stiffness group were elder and had higher serum uric acid compared with those in the control group. Forty-four patients were confirmed to have CAD ; CAD patients in the stiffness group (n = 23) had significantly higher serum iPTH level compared with those in the control group(n =21) (P <0. 05). Multivariate logistic regression model showed that the serum iPTH level was positively correlated with CPP, and independent risk factor of increased central arterial stiffness(CPP > 40 mmHg) after adjustment for age, BMI, hs-CRP, and male gender. Conclusion CAD patients with increased central arterial stiffness and preserved renal function have higher serum PTH level. The serum PTH level is positively correlated with central arterial stiffness ,and is the independent risk factor for increased arterial stiffness.
Keywords：parathyroid hormonecentral arterial stiffnesscoronary artery disease
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 144-146 )