Clinical analysis of serum biochemical parameter changes in patients with chronic kidney disease-mineral and bone disorder

QIU Lin; MA Jian-fei

Abstract：Objective To provide guide for clinical diagnosis, classification and treatment of chronic kidney disease-mineral and bone disorder(CKD-MBD). Methods A total of 56 patients with chronic renal insufficiency were divided into three different groups : CKD4 period, CKD5 period and long-term bemodialysis (over 5 years). Their serum calcium, phosphorus, iPTH, bAP, and TRACP levels, and the bone mineral density were examined. Results The incidences of CKD-MBD in the three groups were 36. 4% ,73.0%, and 87.5% ,respectively. Highturnover bone disease accounted for 65.79%, and the low-turnover bone disease accounted for 34. 21%. The bAP and TRACP activity was significantly increased in patients with high-turnover bone disease and decreased in those with low-turnover bone disease. Conclusion CKD-MBD is a common complication of patients with chronic renal failure, with the main type being high-turnover bone disease, but the low-turnover bone disease can not be ignored. TRACP and bAP are the sensitive indicators of osteoblasts and 9steoclast activity ,and they could be used to identify high or low turnover bone disease. TRACP and bAP, together with serum calcium, phosphorus, iPTH, bone mineral density changes,can be used for a comprehensive analysis of bone metabolic state,so as to guide the diagnosis, sub-typing,drug selection and comprehensive treatment of CKD-MBD.