Effect of body composition on bone mineral density in postmenopausal women with different glucose tolerances

YE Ai-ling; LIU Wei; ZHANG Hong; PENG Yi-qun; HAO Er-yuan

Abstract：Objective To investigate the effect of body composition on bone mineral density(BMD)in postmenopausal women with different glucose tolerances.Methods A total of 152 postmenopausal women aged 45～81 years were divided into two groups according to the results of oral glucose tolerance test,including 41 with 12DM and 111 with normal glucose tolerance(NGT).BMDs of anteroposterior lumbar vertebrae(AP),femeral neck(FN),total hip(T-hip)and the total bone mineral density(TBMD)were mesgured by a dual energy x-ray absorptiometry(DEXA)scan.Body composition was also measilred by DEXA,and the fat tissue mass(FTM),lean tissue mass(LTM),percentage of truncal fat(Tru-fat%)and the total fat(Fat%)were calculated.Results LTM was positively correlated with BMDs at all measured sites in the NGT group,and it was also an independent predictor for BMDs at all sites(Beta=0.199～0.455,R~2C=0.027～0.200,P＜0.01 or 0.05).The percentage of fat showed an inverse relationship with total BMD in NGT,and FTM was also an independent predictor of total BMD(Beta=-0.237,P＜0.05).In T2DM group,LTM had a positive correlation only with BMD of FN and total hip;the percentage of fat also had a positive association with BMD of FN and total hip;FTM was the independent predictor of BMD of FN and hip(Beta=0.427～0.475,R~2C=0.166～0.182,P＜0.01),but not LTM.Conclusion LTM has an decreased protective effect on BMD in postmenopausal women with T2DM,but FTM shows a protective effect on FN and hip of T2DM women.Maintaining a certain weight and strengthening their muscle strength during slimming can help to maintain the bone mass of postmenopausal women with T2DM.